Even though a worker’s occupation is a crucial determinant of temperature-related mortality, only a handful of studies assess its effect across different labor groups. This study contributes to the literature on temperature and mortality by examining the impact of heat and cold across agricultural, informal, blue-collar, white-collar, and unemployed workers. Results show that white-collar workers are significantly more resilient to extreme temperatures than other labor groups, especially the elderly/retired, agrarian, and informal laborers. Additionally, we provide evidence that climate zones influence the effect and that extreme temperatures lead to a higher likelihood of heart attacks, diabetes, and influenza/pneumonia-related mortality.